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Article

Activity and expression of histone acetylases and deacetylases in inflammatory phenotypes of asthma.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Jan 2014

Gunawardhana L P, Gibson P G, Simpson J L, Powell H, Baines K J

Abstract excerpt

BACKGROUND: Histone acetyltransferases (HATs) and histone deacetylases (HDACs) regulate gene expression, yet differences in the activity of these enzymes in the inflammatory phenotypes of asthma are unknown. We hypothesized that neutrophilic asthma (NA) would be associated with increased HAT and decreased HDAC activity. OBJECTIVE: To investigate total HAT/HDAC activity and gene expression in isolated blood...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24355018
DOI: 10.1111/cea.12168

Genes

CREBBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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