Evaluating smooth muscle cells from CaCl2-induced rat aortal expansions as a surrogate culture model for study of elastogenic induction of human aneurysmal cells.

Abstract excerpt

Regression of abdominal aortic aneurysms (AAAs) via regeneration of new elastic matrix is constrained by poor elastin synthesis by adult vascular cells and absence of methods to stimulate the same. We recently showed hyaluronan oligomers (HA-o) and TGF-β1 (termed elastogenic factors) to enhance elastin synthesis and matrix formation by healthy rat aortic smooth muscle cells (RASMCs). We also determined that these...

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