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Article

Comparative phenotypic analysis of primary aortic VSMCs versus TGF - β/PDGF - BB differentiated MSCs in rat.

Tissue & cell - 1 Nov 2026

Soni Pulkit, Rani Diksha, Kumar Manish, Kushwaha Vaibhav, Thapliyal Anurag, Yadav Satyavir, Maurya Shashank Kumar, Dey Sanjay Kumar

Abstract excerpt

In this investigation, two distinct strategies for generating vascular smooth muscle cells (VSMCs) from adult Wistar rats were systematically compared, viz: direct enzymatic isolation from the thoracic aorta and differentiation from bone marrow-derived mesenchymal stem cells (MSCs). Thoracic aorta-derived VSMCs, harvested by stepwise enzymatic (Collagenase Type 1 (3 mg/mL) and Elastase (1 mg/mL)) digestion for...

Read the complete abstract on PubMed

Topics

Animals
Mesenchymal Stem Cells
Cell Differentiation
Rats
Muscle, Smooth, Vascular
Becaplermin

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Transforming Growth Factor beta

Rats, Wistar

Phenotype

Myocytes, Smooth Muscle

Aorta

Cell Movement

Proto-Oncogene Proteins c-sis

Male

Source

Identifiers

PMID: 42335648
DOI: 10.1016/j.tice.2026.103714

Genes

MSC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 20 Oct 2026.

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