Article
Endothelial VEGF sculpts cortical cytoarchitecture.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 11 Sept 2013
Li Suyan, Haigh Katharina, Haigh Jody J, Vasudevan Anju
Abstract excerpt
Current models of brain development support the view that VEGF, a signaling protein secreted by neuronal cells, regulates angiogenesis and neuronal development. Here we demonstrate an autonomous and pivotal role for endothelial cell-derived VEGF that has far-reaching consequences for mouse brain development. Selective deletion of Vegf from endothelial cells resulted in impaired angiogenesis and marked...
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