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Article

Neuron-derived VEGF contributes to cortical and hippocampal development independently of VEGFR1/2-mediated neurotrophism.

Developmental biology - 15 Mar 2020

Okabe Keisuke, Fukada Hugh, Tai-Nagara Ikue, Ando Tomofumi, Honda Takao, Nakajima Kazunori, Takeda Norihiko, Fong Guo-Hua, Ema Masatsugu, Kubota Yoshiaki

Abstract excerpt

Vascular endothelial growth factor (VEGF) is a potent mitogen critical for angiogenesis and organogenesis. Deletion or inhibition of VEGF during development not only profoundly suppresses vascular outgrowth, but significantly affects the development and function of various organs. In the brain, VEGF is thought to not only promote vascular growth, but also directly act on neurons as a neurotrophic factor by...

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Source

Identifiers

PMID: 31790655
DOI: 10.1016/j.ydbio.2019.11.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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