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Article

Structural insights into incorporation of norbornene amino acids for click modification of proteins.

Chembiochem : a European journal of chemical biology - 4 Nov 2013

Schneider Sabine, Gattner Michael J, Vrabel Milan, Flügel Veronika, López-Carrillo Verónica, Prill Stefan, Carell Thomas

Abstract excerpt

Three for two: by using a Methanosarcina mazei PylRS triple mutant (Y306G, Y384F, I405R) the incorporation of two new exo-norbornene-containing pyrrolysine analogues was achieved. X-ray crystallographic analysis led to the identification of the crucial structural elements involved in substrate recognition by the evolved synthetase.

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Share to Amino Acids
Share to Amino Acyl-tRNA Synthetases
Share to Crystallography, X-Ray

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Structure, Tertiary

Source

Identifiers

PMID: 24027216
DOI: 10.1002/cbic.201300435

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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