Article
In Liddle Syndrome, Epithelial Sodium Channel Is Hyperactive Mainly in the Early Part of the Aldosterone-Sensitive Distal Nephron.
Hypertension (Dallas, Tex. : 1979) - 1 Jun 2016
Nesterov Viatcheslav, Krueger Bettina, Bertog Marko, Dahlmann Anke, Palmisano Ralf, Korbmacher Christoph
Abstract excerpt
The epithelial sodium channel (ENaC) is rate limiting for Na(+) absorption in the aldosterone-sensitive distal nephron comprising the late distal convoluted tubule (DCT2), the connecting tubule (CNT), and the entire collecting duct. Liddle syndrome (pseudohyperaldosteronism), a severe form of salt-sensitive hypertension, is caused by gain-of-function mutations of ENaC, but the precise tubular site of increased...
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