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Hereditary breast cancer: ever more pieces to the polygenic puzzle

11 Sept 2013

Abstract excerpt

Several susceptibility genes differentially impact on the lifetime risk for breast cancer. Technological advances over the past years have enabled the detection of genetic risk factors through high-throughput screening of large breast cancer case-control series. High- to intermediate penetrance alleles have now been identified in more than 20 genes involved in DNA damage signalling and repair, and more than 70...

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PMID: 24025454
DOI: 10.1186/1897-4287-11-12

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