Article
Germline DNA variations in breast cancer predisposition and prognosis: a systematic review of the literature.
Cytogenetic and genome research - 1 Jan 2014
Sapkota Yadav
Abstract excerpt
Breast cancer is the most common cancer and the second leading cause of death in women worldwide. The disease is caused by a combination of genetic, environmental, lifestyle, and reproductive risk factors. Linkage and family-based studies have identified many pathological germline mutations, which account for around 20% of the genetic risk of familial breast cancer. In recent years, single nucleotide...
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