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Germline DNA variations in breast cancer predisposition and prognosis: a systematic review of the literature.

Cytogenetic and genome research - 1 Jan 2014

Sapkota Yadav

Abstract excerpt

Breast cancer is the most common cancer and the second leading cause of death in women worldwide. The disease is caused by a combination of genetic, environmental, lifestyle, and reproductive risk factors. Linkage and family-based studies have identified many pathological germline mutations, which account for around 20% of the genetic risk of familial breast cancer. In recent years, single nucleotide...

Topics

Breast Neoplasms
Female
Gene-Environment Interaction
Genetic Linkage
Genetic Predisposition to Disease
Genome-Wide Association Study
Genotype
Germ-Line Mutation
Humans
Penetrance
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Risk Factors

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Identifiers

PMID: 25401968
DOI: 10.1159/000369045

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