Article
Low complexity regions (LCRs) contribute to the hypervariability of the HIV-1 gp120 protein.
Journal of theoretical biology - 7 Dec 2013
María Velasco Ana, Becerra Arturo, Hernández-Morales Ricardo, Delaye Luis, Jiménez-Corona María Eugenia, Ponce-de-Leon Samuel, Lazcano Antonio
Abstract excerpt
Low complexity regions (LCRs) are sequences of nucleic acids or proteins defined by a compositional bias. Their occurrence has been confirmed in sequences of the three cellular lineages (Bacteria, Archaea and Eucarya), and has also been reported in viral genomes. We present here the results of a detailed computer analysis of the LCRs present in the HIV-1 glycoprotein 120 (gp120) encoded by the viral gene env. The...
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