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Article

Mutational pressure makes HIV1 gp120 linear B-cell epitopes shorter and may lead to their disappearance.

Molecular immunology - 1 Apr 2010

Khrustalev Vladislav Victorovich

Abstract excerpt

We showed that nucleotide sequences coding for linear B-cell epitopes of human immunodeficiency virus type 1 (HIV1) gp120 protein are enriched with codons containing cytosine and guanine in their first and second codon positions. Guanine and cytosine are the most mutable nucleotides in HIV1 genes (due to APOBEC3 and APOBEC1 editing of viral DNA and RNA, respectively, as well as due to reverse transcriptase...

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Identifiers

PMID: 20129670
DOI: 10.1016/j.molimm.2010.01.006

Genes

APOBEC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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