Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Levetiracetam resistance: Synaptic signatures & corresponding promoter SNPs in epileptic hippocampi.

Neurobiology of disease - 1 Dec 2013

Grimminger Tanja, Pernhorst Katharina, Surges Rainer, Niehusmann Pitt, Priebe Lutz, von Lehe Marec, Hoffmann Per, Cichon Sven, Schoch Susanne, Becker Albert J

Abstract excerpt

Pharmacoresistance to antiepileptic drugs (AEDs) is a major clinical problem in patients with mesial temporal lobe epilepsy (mTLE). Levetiracetam (LEV) represents a unique type of AED as its high-affinity binding site, the synaptic vesicle protein SV2A, is a component of the presynaptic release machinery. LEV often leads to full seizure control even in previously refractory patients. However, approximately 30% of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anticonvulsants
Share to Drug Resistance

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epilepsy

Share to Hexosyltransferases

Share to Hippocampus

Share to Membrane Proteins

Share to Presynaptic Terminals

Share to Promoter Regions, Genetic

Source

Identifiers

PMID: 24018139
DOI: 10.1016/j.nbd.2013.08.015

Genes

PIGP
LBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Levetiracetam resistance: Synaptic signatures & corresponding promoter SNPs in epileptic hippocampi.PMID 24018139Read ↗

RNA-seq analysis of hippocampal tissues reveals novel candidate genes for drug refractory epilepsy in patients with MTLE-HSSemantic proximity Read ↗

Transcriptomic and genetic analyses reveal potential causal drivers for intractable partial epilepsySemantic proximity Read ↗

Personalized translational epilepsy research - Novel approaches and future perspectives: Part II: Experimental and translational approaches.Semantic proximity Read ↗

Gene expression variance in hippocampal tissue of temporal lobe epilepsy patients corresponds to differential memory performance.Semantic proximity Read ↗

Whole genome sequencing identifies putative associations between genomic polymorphisms and clinical response to the antiepileptic drug <i>levetiracetam</i>Semantic proximity Read ↗

“Transcriptomic Profiling Unveils Novel Therapeutic Options for Drug-Resistant Temporal Lobe Epilepsy”Semantic proximity Read ↗

Systematic review and meta-analysis of differentially expressed miRNAs in experimental and human temporal lobe epilepsy.Semantic proximity Read ↗

Convergent transcriptomic targets of propranolol and primidone identify potential biomarkers for essential tremorSemantic proximity Read ↗

The methylation hypothesis of pharmacoresistance in epilepsySemantic proximity Read ↗

Identification of dysregulated transcription factor activity in temporal lobe epilepsySemantic proximity Read ↗

Pharmacoresponse in Genetic Generalized Epilepsy: A Genome-Wide Association StudySemantic proximity Read ↗

Somatic Ras/Raf/MAPK Variants Enriched in the Hippocampus in Drug-Resistant Mesial Temporal Lobe EpilepsySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.