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Article

Pharmacoresponse in Genetic Generalized Epilepsy: A Genome-Wide Association Study

1 Apr 2020

Abstract excerpt

Aim: Pharmacoresistance is a major burden in epilepsy treatment. We aimed to identify genetic biomarkers in response to specific antiepileptic drugs (AEDs) in genetic generalized epilepsies (GGE). Materials & methods: We conducted a genome-wide association study (GWAS) of 3.3 million autosomal SNPs in 893 European subjects with GGE – responsive or nonresponsive to lamotrigine, levetiracetam and valproic acid....

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PMID: 32308125
DOI: 10.2217/pgs-2019-0179

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