Article

Somatic Ras/Raf/MAPK Variants Enriched in the Hippocampus in Drug-Resistant Mesial Temporal Lobe Epilepsy

2022-12-26

Abstract excerpt

<h4>Importance</h4> Mesial temporal lobe epilepsy (MTLE) is the most common focal epilepsy subtype and is often refractory to anti-seizure medications. While most MTLE patients do not have pathogenic germline genetic variants, the contribution of post-zygotic (i.e., somatic) variants in the brain is unknown. <h4>Objective</h4> To test the association between pathogenic somatic variants in the hippocampus and MTLE....

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Literature Corpus work: b142348a-321d-5e50-88a4-d0d451f2aa60
DOI: 10.1101/2022.12.23.22283854

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