Article
Internalisation of the protease-activated receptor 1: role of the third intracellular loop and of the cytoplasmic tail.
International journal of molecular medicine - 1 Jun 2001
Chen X, Berrou J, Vigneau C, Delarue F, Rondeau E
Abstract excerpt
To analyse the mechanisms of PAR-1 internalisation, we constructed several PAR-1 mutants and stably expressed them in CHO cells. Our study shows that the Ser(306)-->Ala mutation (S306A), which eliminates a potential site of phosphorylation by PKC in the third intracellular loop of PAR-1, did not change the rate of phosphorylation but reduced the rate of thrombin-induced internalisation of the PAR-1 mutant (58...
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