Article
XY female mice resulting from a heritable mutation in the primary testis-determining gene, Tdy.
Development (Cambridge, England) - 1 Jul 1990
Lovell-Badge R, Robertson E
Abstract excerpt
Chimeric mice constructed with XY embryonic stem (ES) cells that had been multiply infected with a retroviral vector were used in a genetic screen to look for mutations affecting the sex determination pathway in mice. From a small number of chimeras screened one was identified that gave rise to a low proportion of XY females amongst his offspring. Analysis of the segregating patterns of retroviral insertions...
Topics
- Animals
- Blotting, Southern
- Chimera
- DNA
- Female
- Genetic Vectors
- Karyotyping
- Mice
- Mutation
- Ovary
- Retroviridae
- Sex Chromosome Aberrations