Article
Mutational analysis of SRY in XY females.
Human mutation - 1 Jan 1993
Hawkins J R
Abstract excerpt
The Y chromosome located gene SRY (sex determining region Y gene) was identified in the search for the mammalian testis determining factor (TDF). Approaches for evaluating SRY as a candidate for TDF included the finding of mutations in SRY in the genomes of patients with failed testis development (XY females or 46,XY gonadal dysgenesis) and the production of female to male sex reversed mice transgenic for the...
Topics
- Amino Acid Sequence
- DNA Mutational Analysis
- DNA-Binding Proteins
- Female
- Gonadal Dysgenesis, 46,XY
- Humans
- Molecular Sequence Data
- Mutation
- Nuclear Proteins
- Sex-Determining Region Y Protein
- Transcription Factors
- Y Chromosome