Article
SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive.
Cell - 23 Dec 2011
Libert Sergiy, Pointer Kelli, Bell Eric L, Das Abhirup, Cohen Dena E, Asara John M, Kapur Karen, Bergmann Sven, Preisig Martin, Otowa Takeshi, Kendler Kenneth S, Chen Xiangning, Hettema John M, van den Oord Edwin J, Rubio Justin P, Guarente Leonard
Abstract excerpt
SIRT1 is a NAD(+)-dependent deacetylase that governs a number of genetic programs to cope with changes in the nutritional status of cells and organisms. Behavioral responses to food abundance are important for the survival of higher animals. Here we used mice with increased or decreased brain SIRT1 to show that this sirtuin regulates anxiety and exploratory drive by activating transcription of the gene encoding...
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