Negative reciprocal regulation between Sirt1 and Per2 modulates the circadian clock and aging

Abstract excerpt

Sirtuin 1 (SIRT1) is involved in both aging and circadian-clock regulation, yet the link between the two processes in relation to SIRT1 function is not clear. Using Sirt1-deficient mice, we found that Sirt1 and Period 2 (Per2) constitute a reciprocal negative regulation loop that plays important roles in modulating hepatic circadian rhythmicity and aging. Sirt1-deficient mice exhibited profound premature aging...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Circadian rhythm and melatonin
• Share to Genetics, Aging, and Longevity in Model Organisms
• Share to Sirtuins and Resveratrol in Medicine