Article
Behavioral deficits during early stages of aging in Caenorhabditis elegans result from locomotory deficits possibly linked to muscle frailty.
The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Dec 2004
Glenn Charles F, Chow David K, David Lawrence, Cooke Carol A, Gami Minaxi S, Iser Wendy B, Hanselman Keaton B, Goldberg Ilya G, Wolkow Catherine A
Abstract excerpt
Many behavioral responses require the coordination of sensory inputs with motor outputs. Aging is associated with progressive declines in both motor function and muscle structure. However, the consequences of age-related motor deficits on behavior have not been clearly defined. Here, we examined the effects of aging on behavior in the nematode, Caenorhabditis elegans. As animals aged, mild locomotory deficits...
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