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Article

Genetic analysis of age-dependent defects of the Caenorhabditis elegans touch receptor neurons.

Proceedings of the National Academy of Sciences of the United States of America - 31 May 2011

Pan Chun-Liang, Peng Chiu-Ying, Chen Chun-Hao, McIntire Steven

Abstract excerpt

Although many genes have been implicated in the pathogenesis of common neurodegenerative diseases, the genetic and cellular mechanisms that maintain neuronal integrity during normal aging remain elusive. Here we show that Caenorhabditis elegans touch receptor and cholinergic neurons display age-dependent morphological defects, including cytoskeletal disorganization, axon beading, and defasciculation. Progression...

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Identifiers

PMID: 21571636
DOI: 10.1073/pnas.1011711108
PMCID: PMC3107274

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