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Addressing osteoblast senescence: Molecular pathways and the frontier of anti‐ageing treatments

1 Jul 2025

Abstract excerpt

BACKGROUND: Osteoblast senescence is a central driverof age-related osteoporosis. Accumulating evidence shows that counteractingthis senescence can substantially mitigate bone loss. In this review, we summarize the hallmarks of osteoblast senescence, the signaling pathways involved, and therapeutic strategies that target osteoblast senescence tocombat age-related osteoporosis. METHODS: Chronic diseases associated...

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PMID: 40681473
DOI: 10.1002/ctm2.70417

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