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Article

High multiplicity HIV-1 cell-to-cell transmission from macrophages to CD4+ T cells limits antiretroviral efficacy

21 May 2013

Abstract excerpt

OBJECTIVE: Few studies have examined the efficacy of antiretroviral therapy (ART) in the context of cell-to-cell transmission. We aimed to determine whether the activity of ART is limited by the mode of HIV-1 spread between cells and the type of immune cell implicated in transmission, or is independent of these variables. DESIGN: ART activity was evaluated in primary cells using in-vitro cell-free and cell...

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PMID: 24005480
DOI: 10.1097/qad.0b013e3283632ec4

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