Article

Host Restriction Factors Modulating HIV Latency and Replication in Myeloid Cells

2021-11-23

Abstract excerpt

In addition to CD4+ T lymphocytes, myeloid cells, and, particularly, differentiated macrophages, are targets of the human immunodeficiency virus type-1 (HIV-1) infection via interaction of gp120Env with CD4 and CCR5 or CXCR4. Both T cells and macrophages support virus replication although with substantial differences. In contrast to activated CD4+ T lymphocytes, HIV-1 replication in macrophages occurs in nondividi...

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Literature Corpus work: b71c8925-b743-593e-bbb2-353948d54214
DOI: 10.20944/preprints202111.0439.v1

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