Article

CD4+ T cells facilitate replication of primary HIV-1 strains in macrophages and formation of macrophage internal virus-containing compartments

2024-03-24

Abstract excerpt

<h4>ABSTRACT</h4> HIV-1 infects CD4+ T cells and macrophages. However, replication of HIV-1 in these cell types is highly variable and may depend on the use of CCR5 as a co-receptor. In addition, there is internal accumulation of infectious HIV-1 in so-called virus-containing compartments of macrophages (VCCs). VCCs are thought to represent a persistent viral reservoir that is shielded from the antiviral immune r...

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Literature Corpus work: aa0a5f9d-a664-5c3b-a641-cec73aacb3ab
DOI: 10.1101/2024.03.22.586250

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