Article
UBE2QL1 is disrupted by a constitutional translocation associated with renal tumor predisposition and is a novel candidate renal tumor suppressor gene.
Human mutation - 1 Dec 2013
Wake Naomi C, Ricketts Christopher J, Morris Mark R, Prigmore Elena, Gribble Susan M, Skytte Anne-Bine, Brown Michael, Clarke Noel, Banks Rosamonde E, Hodgson Shirley, Turnell Andrew S, Maher Eamonn R, Woodward Emma R
Abstract excerpt
Investigation of rare familial forms of renal cell carcinoma (RCC) has led to the identification of genes such as VHL and MET that are also implicated in the pathogenesis of sporadic RCC. In order to identify a novel candidate renal tumor suppressor gene, we characterized the breakpoints of a constitutional balanced translocation, t(5;19)(p15.3;q12), associated with familial RCC and found that a previously...
Topics
- Adult
- Base Sequence
- Cell Cycle Proteins
- Cell Line, Tumor
- Cell Proliferation
- Cell Transformation, Neoplastic
- Chromosome Breakpoints
- Chromosomes, Human, Pair 19
- Chromosomes, Human, Pair 5