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Article

Derivative Chromosome 3 Loss from t(3;6)(q12;q14) Followed by Differential VHL Mutations Underlie Multifocal ccRCC.

Cancer genomics & proteomics - 1 Jan 2000

Mizutani Kosuke, Yokoi Shigeaki, Sawada Seiya, Sakamoto Ippei, Kameyama Koji, Kamei Shingo, Hirade Kouseki, Sugiyama Seiji, Matsunaga Kengo, Yamada Tetsuya, Kato Yasutaka, Nishihara Hiroshi, Ishihara Satoshi, Deguchi Takashi

Abstract excerpt

BACKGROUND/AIM: The Von Hippel-Lindau (VHL) gene encodes a protein (pVHL) that plays an important role in proteasome degradation of hypoxia inducible factor α (HIFα) through E3 activation. Accumulation of HIFα by loss of functional pVHL promotes tumorigenesis, thus, VHL has tumor suppressor gene capability in clear cell renal cell carcinoma (ccRCC). VHL is the most frequently mutated gene in ccRCC. The complete...

Topics

Female
Humans
Aged
Carcinoma, Renal Cell
Chromosomes, Human, Pair 3
Kidney Neoplasms
Mutation
Translocation, Genetic
Von Hippel-Lindau Tumor Suppressor Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36316043
DOI: 10.21873/cgp.20356
PMCID: PMC9620442

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