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Article

Familial clear cell renal cell carcinoma (FCRC): clinical features and mutation analysis of the VHL,MET, and CUL2candidate genes

1 May 2000

Abstract excerpt

Familial renal cell carcinoma (RCC) is genetically heterogeneous. Genetic predisposition to clear cell RCC (CCRCC) is a major feature of von Hippel-Lindau (VHL) disease (MIM 193300) and has rarely been associated with chromosome 3 translocations. In addition, familial papillary (non-clear cell) RCC may result from germline mutations in the MET proto-oncogene (MIM 164860). However, rare kindreds with familial...

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Identifiers

PMID: 10807693
DOI: 10.1136/jmg.37.5.348

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