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Article

ELOC-Mutated Renal Cell Carcinoma is a Rare Indolent Tumor With Distinctive Genomic Characteristics.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Aug 2025

Wang Jasmine J, Huang Rong Rong, Cone Brian D, Kang Sung-Hae L, Setoodeh Reza, Sisk Anthony E, Sajed Dipti P, Shuch Brian M, Sowalsky Adam G, Ye Huihui

Abstract excerpt

ELOC-mutated renal cell carcinoma (ELOC-RCC) is a subtype of RCC first recognized by the World Health Organization in 2022, molecularly defined by the presence of ELOC mutations and the lack of VHL mutations. Here, we present an institutional series of ELOC-RCC and provide an in-depth genetic comparison to VHL-null clear cell RCC (VHL-ccRCCs). Among 1209 RCCs in our institutional cytogenetics database, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40246078
DOI: 10.1016/j.modpat.2025.100777
PMCID: PMC12478993

Genes

ELOC
VHL
BAP1
PBRM1
SETD2
TSC1
TSC2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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