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Article

Ursodeoxycholic Acid Improves Mitochondrial Function and Redistributes Drp1 in Fibroblasts from Patients with Either Sporadic or Familial Alzheimer's Disease.

Journal of molecular biology - 19 Oct 2018

Bell Simon M, Barnes Katy, Clemmens Hannah, Al-Rafiah Aziza R, Al-Ofi Ebtisam A, Leech Vicki, Bandmann Oliver, Shaw Pamela J, Blackburn Daniel J, Ferraiuolo Laura, Mortiboys Heather

Abstract excerpt

Alzheimer's disease (AD) is the leading cause of dementia worldwide. Mitochondrial abnormalities have been identified in many cell types in AD, with deficits preceding the development of the classical pathological aggregations. Ursodeoxycholic acid (UDCA), a treatment for primary biliary cirrhosis, improves mitochondrial function in fibroblasts derived from Parkinson's disease patients as well as several animal...

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Identifiers

PMID: 30171839
DOI: 10.1016/j.jmb.2018.08.019
PMCID: PMC6193139

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PSEN1

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