Article
NUP98-NSD1 fusion in association with FLT3-ITD mutation identifies a prognostically relevant subgroup of pediatric acute myeloid leukemia patients suitable for monitoring by real time quantitative PCR.
Genes, chromosomes & cancer - 1 Nov 2013
Akiki Susanna, Dyer Sara A, Grimwade David, Ivey Adam, Abou-Zeid Nervana, Borrow Julian, Jeffries Sally, Caddick Judith, Newell Hayley, Begum Suriya, Tawana Kiran, Mason Joanne, Velangi Mark, Griffiths Michael
Abstract excerpt
The cytogenetically cryptic t(5;11)(q35;p15) leading to the NUP98-NSD1 fusion is a rare but recurrent gene rearrangement recently reported to identify a group of young AML patients with poor prognosis. We used reverse transcription polymerase chain reaction (PCR) to screen retrospectively diagnostic samples from 54 unselected pediatric AML patients and designed a real time quantitative PCR assay to track...
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