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Article

A novel gene, NSD1, is fused to NUP98 in the t(5;11)(q35;p15.5) in de novo childhood acute myeloid leukemia

15 Aug 2001

Abstract excerpt

The recurrent translocation t(5;11)(q35;p15.5) associated with a 5q deletion, del(5q), has been reported in childhood acute myeloid leukemia (AML). We report the cloning of the translocation breakpoints in de novo childhood AML harboring a cryptic t(5;11)(q35;p15.5). Fluorescence in situ hybridization (FISH) analysis demonstrated that the nucleoporin gene (NUP98) at 11p15.5 was disrupted by this translocation. By...

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Identifiers

PMID: 11493482
DOI: 10.1182/blood.v98.4.1264

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Related research

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Research trail→

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A novel gene, NSD1, is fused to NUP98 in the t(5;11)(q35;p15.5) in de novo childhood acute myeloid leukemiaPMID 11493482Read ↗

NUP98 ‐ NSD1 gene fusion and its related gene expression signature are strongly associated with a poor prognosis in pediatric acute myeloid leukemiaSemantic proximity Read ↗

NUP98 is fused to the NSD3 gene in acute myeloid leukemia associated with t(8;11)(p11.2;p15)Semantic proximity Read ↗

The inv(11)(p15q22) Chromosome Translocation of De Novo and Therapy-Related Myeloid Malignancies Results in Fusion of the Nucleoporin Gene, NUP98, With the Putative RNA Helicase Gene, DDX10Semantic proximity Read ↗

NUP98/NSD1 characterizes a novel poor prognostic group in acute myeloid leukemia with a distinct HOX gene expression patternSemantic proximity Read ↗

Identification of NUP98-NSD1 interactors and their implication in acute myeloid leukemiaSemantic proximity Read ↗

NUP98::NSD1 and FLT3-ITD collaborate to generate acute myeloid leukemiaSemantic proximity Read ↗

Clinical whole-genome sequencing identifies NSD3 as the correct fusion partner of NUP98 in a patient with acute myeloid leukemia and t(8;11)(p11.2;p15): a case reportSemantic proximity Read ↗

NUP98-NSD1 fusion in association with FLT3-ITD mutation identifies a prognostically relevant subgroup of pediatric acute myeloid leukemia patients suitable for monitoring by real time quantitative PCR.Semantic proximity Read ↗

NUP98 is rearranged in 3.8% of pediatric AML forming a clinical and molecular homogenous group with a poor prognosis.Semantic proximity Read ↗

NUP98/11p15 translocations affect CD34+ cells in myeloid and T lymphoid leukemias.Semantic proximity Read ↗

NUP98-NSD1 links H3K36 methylation to Hox-A gene activation and leukaemogenesis.Semantic proximity Read ↗

NUP98–NSD3 fusion gene in radiation-associated myelodysplastic syndrome with t(8;11)(p11;p15) and expression pattern of NSD family genesSemantic proximity Read ↗

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