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Article

Epithelial stem cell mutations that promote squamous cell carcinoma metastasis

2 Sept 2013

Abstract excerpt

Squamous cell carcinomas (SCCs) originate in stratified epithelia, with a small subset becoming metastatic. Epithelial stem cells are targets for driver mutations that give rise to SCCs, but it is unknown whether they contribute to oncogenic multipotency and metastasis. We developed a mouse model of SCC by targeting two frequent genetic mutations in human SCCs, oncogene Kras(G12D) activation and Smad4 deletion,...

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PMID: 23999427
DOI: 10.1172/jci65856

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