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KRAS activation in gastric cancer stem-like cells promotes tumor angiogenesis and metastasis

2022-12-06

Abstract excerpt

<title>Abstract</title> <p>Our previous work showed that KRAS activation in gastric cancer cells leads to activation of an epithelial-to-mesenchymal transition (EMT) program and generation of cancer stem-like cells (CSCs). Here we analyze how this KRAS activation in gastric CSCs promotes tumor angiogenesis and metastasis. Gastric cancer CSCs were found to secrete pro-angiogenic factors such as vascular endothelia...

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Literature Corpus work
112fc6ec-91d3-5ecd-95cf-e46dc8e0166d
DOI
10.21203/rs.3.rs-2117637/v1
Open publication

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