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Stem-cell states converge in multistage cutaneous squamous cell carcinoma development

30 May 2024

Abstract excerpt

Stem cells play a critical role in cancer development by contributing to cell heterogeneity, lineage plasticity, and drug resistance. We created gene expression networks from hundreds of mouse tissue samples (both normal and tumor) and integrated these with lineage tracing and single-cell RNA-seq, to identify convergence of cell states in premalignant tumor cells expressing markers of lineage plasticity and drug...

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PMID: 38815020
DOI: 10.1126/science.adi7453

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