Article
SLUG is required for SOX9 stabilization and functions to promote cancer stem cells and metastasis in human lung carcinoma.
Oncogene - 2 Jun 2016
Luanpitpong S, Li J, Manke A, Brundage K, Ellis E, McLaughlin S L, Angsutararux P, Chanthra N, Voronkova M, Chen Y C, Wang L, Chanvorachote P, Pei M, Issaragrisil S, Rojanasakul Y
Abstract excerpt
Cancer stem cells (CSCs) are a promising target for cancer therapy, particularly for metastatic lung cancers, but how CSCs are regulated is largely unknown. We identify two proteins, SLUG (encoded by SNAI2 gene) and SOX9, which are associated with advanced stage lung cancers and are implicated in the regulation of CSCs. Inhibition of either SLUG or SOX9 sufficiently inhibits CSCs in human lung cancer cells and...
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