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Article

HLA-B13, B35 and B*39 Alleles Are Closely Associated With the Lack of Response to ART in HIV Infection: A Cohort Study in a Population of Northern Brazil.

Frontiers in immunology - 1 Jan 2022

Pereira Leonn Mendes Soares, França Eliane Dos Santos, Costa Iran Barros, Jorge Erika Vanessa Oliveira, Mattos Patrícia Jeanne de Souza Mendonça, Freire Amaury Bentes Cunha, Ramos Francisco Lúzio de Paula, Monteiro Talita Antonia Furtado, Macedo Olinda, Sousa Rita Catarina Medeiros, Dos Santos Eduardo José Melo, Freitas Felipe Bonfim, Costa Igor Brasil, Vallinoto Antonio Carlos Rosário

Abstract excerpt

Introduction: Immune reconstitution failure after HIV treatment is a multifactorial phenomenon that may also be associated with a single polymorphism of human leukocyte antigen (HLA); however, few reports include patients from the Brazilian Amazon. Our objective was to evaluate the association of the immunogenic profile of the "classical" HLA-I and HLA-II loci with treatment nonresponse in a regional cohort...

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Identifiers

PMID: 35371095
DOI: 10.3389/fimmu.2022.829126
PMCID: PMC8966405

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