Article
High frequency neural spiking and auditory signaling by ultrafast red-shifted optogenetics.
Nature communications - 1 May 2018
Mager Thomas, Lopez de la Morena David, Senn Verena, Schlotte Johannes, D Errico Anna, Feldbauer Katrin, Wrobel Christian, Jung Sangyong, Bodensiek Kai, Rankovic Vladan, Browne Lorcan, Huet Antoine, Jüttner Josephine, Wood Phillip G, Letzkus Johannes J, Moser Tobias, Bamberg Ernst
Abstract excerpt
Optogenetics revolutionizes basic research in neuroscience and cell biology and bears potential for medical applications. We develop mutants leading to a unifying concept for the construction of various channelrhodopsins with fast closing kinetics. Due to different absorption maxima these channelrhodopsins allow fast neural photoactivation over the whole range of the visible spectrum. We focus our functional...
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