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Article

Calmodulin modulates the termination threshold for cardiac ryanodine receptor-mediated Ca2+ release.

The Biochemical journal - 1 Nov 2013

Tian Xixi, Tang Yijun, Liu Yingjie, Wang Ruiwu, Chen S R Wayne

Abstract excerpt

RyR2 (cardiac ryanodine receptor)-mediated Ca2+ release in cardiomyocytes terminates when the sarcoplasmic reticulum Ca2+ content depletes to a threshold level, known as the termination threshold. Despite its importance, little is known about the mechanism that regulates the termination threshold. CaM (calmodulin), by inhibiting RyR2, has been implicated in Ca2+-release termination, but whether CaM modulates the...

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Identifiers

PMID: 23992453
DOI: 10.1042/BJ20130805

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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