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Article

Functional reconstitution of endothelial nitric oxide synthase reveals the importance of serine 1179 in endothelium-dependent vasomotion.

Circulation research - 3 May 2002

Scotland Ramona S, Morales-Ruiz Manuel, Chen Yan, Yu Jun, Rudic Radu Daniel, Fulton David, Gratton Jean-Philippe, Sessa William C

Abstract excerpt

Phosphorylation of endothelial nitric oxide synthase (eNOS) at serine 1179 can activate the enzyme, leading to NO release. Because eNOS is important in regulating vascular tone, we investigated whether phosphorylation of this residue is involved in vasomotion. Adenoviral transduction of endothelial cells (ECs) with the phosphomimetic S1179DeNOS markedly increased basal and vascular endothelial cell growth factor...

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Identifiers

PMID: 11988492
DOI: 10.1161/01.res.0000016506.04193.96

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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