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Article

Virulence variation among isolates of western equine encephalitis virus in an outbred mouse model.

The Journal of general virology - 1 Aug 2009

Logue Christopher H, Bosio Christopher F, Welte Thomas, Keene Kimberley M, Ledermann Jeremy P, Phillips Aaron, Sheahan Brian J, Pierro Dennis J, Marlenee Nicole, Brault Aaron C, Bosio Catharine M, Singh Amber J, Powers Ann M, Olson Ken E

Abstract excerpt

Little is known about viral determinants of virulence associated with western equine encephalitis virus (WEEV). Here, we have analysed six North American WEEV isolates in an outbred CD1 mouse model. Full genome sequence analyses showed < or =2.7 % divergence among the six WEEV isolates. However, the percentage mortality and mean time to death (MTD) varied significantly when mice received subcutaneous injections...

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Identifiers

PMID: 19403754
DOI: 10.1099/vir.0.008656-0
PMCID: PMC2887574

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Source receipt: pubmed, retrieved 7 Sept 2026.

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