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Development of a universal radioactive DNA methyltransferase inhibition test for high-throughput screening and mechanistic studies

24 Aug 2013

Abstract excerpt

DNA methylation is an important epigenetic mark in eukaryotes, and aberrant pattern of this modification is involved in numerous diseases such as cancers. Interestingly, DNA methylation is reversible and thus is considered a promising therapeutic target. Therefore, there is a need for identifying new small inhibitors of C5 DNA methyltransferases (DNMTs). Despite the development of numerous in vitro DNMT assays,...

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PMID: 23980028
DOI: 10.1093/nar/gkt753

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