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Article

Effects of KCNQ2 gene truncation on M-type Kv7 potassium currents.

PloS one - 1 Jan 2013

Robbins Jon, Passmore Gayle M, Abogadie Fe C, Reilly Joanne M, Brown David A

Abstract excerpt

The KCNQ2 gene product, Kv7.2, is a subunit of the M-channel, a low-threshold voltage-gated K(+) channel that regulates mammalian and human neuronal excitability. Spontaneous mutations one of the KCNQ2 genes cause disorders of neural excitability such as Benign Familial Neonatal Seizures. However...

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Source

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Identifiers

PMID: 23977150
DOI: 10.1371/journal.pone.0071809
PMCID: PMC3748097

Genes

KCNQ2
KCNQ3
KCNQ5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23977150-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Effects of KCNQ2 gene truncation on M-type Kv7 potassium currents.PMID 23977150Read ↗

Differential Expression of KCNQ2 Splice Variants: Implications to M Current Function during Neuronal DevelopmentSemantic proximity Read ↗

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A spontaneous mutation involving Kcnq2 (Kv7.2) reduces M-current density and spike frequency adaptation in mouse CA1 neurons.Semantic proximity Read ↗

Peripheral nerve hyperexcitability due to dominant-negative KCNQ2 mutations.Semantic proximity Read ↗

Disruption of the epilepsy KCNQ2 gene results in neural hyperexcitability.Semantic proximity Read ↗

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