Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Disruption of the epilepsy KCNQ2 gene results in neural hyperexcitability.

Journal of neurochemistry - 1 Jul 2000

Watanabe H, Nagata E, Kosakai A, Nakamura M, Yokoyama M, Tanaka K, Sasai H

Abstract excerpt

Benign familial neonatal convulsion (BFNC) is a common idiopathic epilepsy with autosomal dominant inheritance. Recently, two novel voltage-dependent potassium channel genes, KCNQ2 and KCNQ3, were identified by positional cloning as being responsible for BFNC. Heterotetramers of the products of t...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Catecholamines
Share to Electroencephalography
Share to Epilepsy, Benign Neonatal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Targeting

Share to KCNQ2 Potassium Channel

Share to Pentylenetetrazole

Share to Potassium Channels

Share to Potassium Channels, Voltage-Gated

Source

Identifiers

PMID: 10854243
DOI: 10.1046/j.1471-4159.2000.0750028.x

Genes

KCNQ2
KCNQ3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-10854243-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Disruption of the epilepsy KCNQ2 gene results in neural hyperexcitability.PMID 10854243Read ↗

A novel potassium channel gene, KCNQ2, is mutated in an inherited epilepsy of newborns.Semantic proximity Read ↗

KCNQ2 and KCNQ3 potassium channel genes in benign familial neonatal convulsions: expansion of the functional and mutation spectrum.Semantic proximity Read ↗

Functional analysis of novel KCNQ2 mutations found in patients with Benign Familial Neonatal Convulsions.Semantic proximity Read ↗

Clinical analysis and functional characterization of KCNQ2-related developmental and epileptic encephalopathySemantic proximity Read ↗

Mouse models of human KCNQ2 and KCNQ3 mutations for benign familial neonatal convulsions show seizures and neuronal plasticity without synaptic reorganization.Semantic proximity Read ↗

A reduced K+ current due to a novel mutation in KCNQ2 causes neonatal convulsions.Semantic proximity Read ↗

KCNQ2/KCNQ3 K+ channels and the molecular pathogenesis of epilepsy: implications for therapy.Semantic proximity Read ↗

A de novo KCNQ2 mutation detected in non-familial benign neonatal convulsions.Semantic proximity Read ↗

KCNQ2-Associated Epilepsy: A Review of Variable Phenotypes and Neurodevelopmental OutcomesSemantic proximity Read ↗

A Potassium Channel Mutation in Neonatal Human EpilepsySemantic proximity Read ↗

Mouse models of Kcnq2 dysfunction.Semantic proximity Read ↗

[Benign familial neonatal convulsions: molecular pathology and diagnosis].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.