Article
Peripheral nerve hyperexcitability due to dominant-negative KCNQ2 mutations.
Neurology - 27 Nov 2007
Wuttke T V, Jurkat-Rott K, Paulus W, Garncarek M, Lehmann-Horn F, Lerche H
Abstract excerpt
BACKGROUND: Peripheral nerve hyperexcitability (PNH) is characterized by muscle overactivity due to spontaneous discharges of lower motor neurons usually associated with antibodies against voltage-gated potassium channels. PNH may also occur in combination with episodic ataxia or epilepsy caused by mutations in K(V)1.1 or K(V)7.2 channels. Only one PNH-associated mutation has been described so far in K(V)7.2...
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