Effect of Alcohol Consumption on CpG Methylation in the Differentially Methylated Regions of <i>H19</i> and <i>IG‐DMR</i> in Male Gametes—Implications for Fetal Alcohol Spectrum Disorders

Abstract excerpt

BACKGROUND: Exposure to alcohol in utero is the main attributable cause of fetal alcohol spectrum disorders (FASD) which in its most severe form is characterized by irreversible behavioral and cognitive disability. Paternal preconception drinking is not considered to be a significant risk factor, even though animal studies have demonstrated that chronic paternal alcohol consumption has a detrimental effect on the...

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