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Idiopathic male infertility is strongly associated with aberrant methylation of <i>MEST</i> and <i>IGF2/H19 ICR1</i>

30 Oct 2009

Abstract excerpt

Aberrant imprinting in spermatozoa in a subset of infertile men has been postulated to be a risk factor for congenital diseases in children conceived via assisted reproduction techniques (ART). Studies in clinically well characterized large cohorts, however, have been missing. Using bisulfite sequencing, we determined the degree of methylation of the IGF2/H19 imprinting control region 1 (ICR1) and MEST...

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PMID: 19878521
DOI: 10.1111/j.1365-2605.2009.01000.x

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