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Sperm DNA methylation ofH19imprinted gene and male infertility

15 Mar 2017

Abstract excerpt

Infertility affects up to 15% of reproductive-aged couples worldwide, with male factor being detected in 40%-50% of the cases. Proper sperm production is associated with the establishment of appropriate epigenetic marks in developing germ cells. Several studies have demonstrated the association between abnormal spermatogenesis and epigenetic disturbances with the major focus on DNA methylation. Imprinted genes...

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Share to Prenatal Screening and Diagnostics
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PMID: 28295500
DOI: 10.1111/and.12766

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