Article
A genome-wide association study of chronic otitis media with effusion and recurrent otitis media identifies a novel susceptibility locus on chromosome 2.
Journal of the Association for Research in Otolaryngology : JARO - 1 Dec 2013
Allen E Kaitlynn, Chen Wei-Min, Weeks Daniel E, Chen Fang, Hou Xuanlin, Mattos José L, Mychaleckyj Josyf C, Segade Fernando, Casselbrant Margaretha L, Mandel Ellen M, Ferrell Robert E, Rich Stephen S, Daly Kathleen A, Sale Michèle M
Abstract excerpt
Chronic otitis media with effusion (COME) and recurrent otitis media (ROM) have been shown to be heritable, but candidate gene and linkage studies to date have been equivocal. Our aim was to identify genetic susceptibility factors using a genome-wide association study (GWAS). We genotyped 602 subjects from 143 families with 373 COME/ROM subjects using the Illumina Human CNV370-Duo DNA Bead Chip (324,748 SNPs). We...
Topics
- Chromosomes, Human, Pair 2
- Chronic Disease
- Female
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Linkage Disequilibrium
- Male
- Otitis Media