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Article

Otitis media: a genome-wide linkage scan with evidence of susceptibility loci within the 17q12 and 10q22.3 regions.

BMC medical genetics - 3 Sept 2009

Casselbrant Margaretha L, Mandel Ellen M, Jung Jeesun, Ferrell Robert E, Tekely Kathleen, Szatkiewicz Jin P, Ray Amrita, Weeks Daniel E

Abstract excerpt

BACKGROUND: Otitis media (OM) is a common worldwide pediatric health care problem that is known to be influenced by genetics. The objective of our study was to use linkage analysis to map possible OM susceptibility genes. METHODS: Using a stringent diagnostic model in which only those who underwent tympanostomy tube insertion at least once for recurrent/persistent OM are considered affected, we have carried out a...

Topics

Black or African American
Child
Child, Preschool
Chromosomes, Human, Pair 10
Chromosomes, Human, Pair 7
Female
Gene Frequency
Genetic Linkage
Genetic Predisposition to Disease
Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Male

Otitis Media

Polymorphism, Single Nucleotide

White People

Source

Open in PubMed Open full text

Identifiers

PMID: 19728873
DOI: 10.1186/1471-2350-10-85
PMCID: PMC2751750

Genes

SFTPA2
CCL5
IFNG
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Otitis media: a genome-wide linkage scan with evidence of susceptibility loci within the 17q12 and 10q22.3 regions.PMID 19728873Read ↗

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Genome-wide association study to identify the genetic determinants of otitis media susceptibility in childhood.Semantic proximity Read ↗

A genome-wide association study of chronic otitis media with effusion and recurrent otitis media identifies a novel susceptibility locus on chromosome 2.Semantic proximity Read ↗

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Genome-wide association study for acute otitis media in children identifies FNDC1 as disease contributing geneSemantic proximity Read ↗

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